5-Amino-1MQ

Preclinical only Weight Loss & Metabolism In 1 protocol 2 sources

5-Amino-1MQ is a small molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Research in animal models suggests that inhibiting NNMT can increase NAD+ levels, boost cellular metabolism, and reduce fat mass without altering food intake.

01Dosing reference

Amount

50-150 mg/day

Frequency

1-3 times daily (oral)

Cycle

4-8 weeks on, followed by a break

Reference figures, not a recommendationThese values reflect amounts described in the literature and vendor documentation this database indexes. Use the reconstitution calculator to convert them into syringe units.

02Mechanism of action

NNMT Inhibition

5-Amino-1MQ binds to and inhibits the enzyme nicotinamide N-methyltransferase (NNMT), which is often overexpressed in fat tissue.

NAD+ Preservation

By blocking NNMT, the compound prevents the depletion of nicotinamide, leading to an increase in the salvage pathway production of NAD+.

Metabolic Activation

Elevated NAD+ levels activate sirtuins and other metabolic pathways, increasing energy expenditure and promoting the breakdown of fat cells.

03Human evidence

Lack of clinical trials

Currently, there are no published human clinical trials evaluating the safety or efficacy of 5-Amino-1MQ for weight loss or metabolic enhancement in humans.

04Preclinical evidence

Reduction in body weight and fat mass

In diet-induced obese mice, 5-Amino-1MQ treatment resulted in a significant decrease in body weight and white adipose tissue mass without changes in food intake.

Reversal of diet-induced obesity

Mouse models showed that NNMT inhibition by 5-Amino-1MQ improved metabolic parameters, including cholesterol levels and lipogenesis.

05What is known vs. unknown

Reasonably established

5-Amino-1MQ is a targeted inhibitor of the NNMT enzyme.
Animal studies show it can reduce body weight and fat mass without suppressing appetite.
It works by increasing intracellular NAD+ levels, which boosts cellular energy metabolism.
It is a small molecule, not a traditional peptide, and is orally bioavailable in research settings.

Unknowns & limits

There is a complete lack of human clinical data regarding its safety, efficacy, and optimal dosing.
Long-term effects of chronic NNMT inhibition in humans are unknown.
Potential off-target effects or interactions with other metabolic pathways have not been fully characterized.

06Safety & regulatory context

Regulatory status5-Amino-1MQ is an experimental research chemical and is not approved by the FDA for human use. Because it has only been studied in preclinical animal models, its safety profile, potential side effects, and contraindications in humans are entirely unknown. It should be handled strictly for laboratory research purposes.

07Compared with NMN (Nicotinamide Mononucleotide)

5-Amino-1MQ vs. NMN (Nicotinamide Mononucleotide)

Key difference

NMN directly supplies a precursor to boost NAD+ levels, whereas 5-Amino-1MQ prevents the breakdown/depletion of NAD+ precursors by inhibiting the NNMT enzyme.

When researchers discuss each

Researchers discuss NMN when looking to supplement NAD+ precursors directly, and 5-Amino-1MQ when exploring targeted enzymatic inhibition to reverse metabolic dysfunction in obesity.

08Appears in protocols

🔥 Fat Loss Starter Protocol

100 mg/day (SubQ)Daily

09Glossary

NNMT

Nicotinamide N-methyltransferase, an enzyme that plays a role in cellular metabolism and energy balance, often found in high levels in fat tissue.

NAD+

Nicotinamide adenine dinucleotide, a crucial coenzyme found in all living cells that is essential for energy production and metabolic regulation.

Small Molecule

A low molecular weight organic compound that may help regulate a biological process, distinct from larger proteins or peptides.

10Knowledge check

Q1What is the primary mechanism of action for 5-Amino-1MQ?

Q2Based on preclinical studies, how does 5-Amino-1MQ affect food intake in animal models?

Q3Which of the following best describes a documented limitation of the current evidence on 5-Amino-1MQ?

Q4How does the dossier distinguish 5-Amino-1MQ from NMN when researchers decide how to raise cellular NAD+?

Q5Which statement about the regulatory and safety status of 5-Amino-1MQ is supported by the dossier?

11Sources

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Research and educational use onlyNothing on this site is medical advice, a prescription, or a recommendation for human use. Compounds documented here are research chemicals. Consult a qualified clinician before making any health decision.