Cortistatin

Preclinical only Immune Support 2 sources

Cortistatin is a neuropeptide structurally related to somatostatin that exhibits potent anti-inflammatory, immunomodulatory, and neuroprotective properties. Research indicates it can deactivate inflammatory responses and promote immune tolerance, making it a subject of interest for autoimmune and inflammatory conditions.

01Dosing reference

Amount

Unknown (typically 1-10 mcg/kg in animal models)

Frequency

Varies by study design

Cycle

Not established for human use

Reference figures, not a recommendationThese values reflect amounts described in the literature and vendor documentation this database indexes. Use the reconstitution calculator to convert them into syringe units.

02Mechanism of action

Receptor Binding

Cortistatin binds to all five somatostatin receptors (SSTR1-5) and uniquely to the ghrelin receptor (GHSR1a).

Immune Cell Modulation

It downregulates the production of pro-inflammatory cytokines (like TNF-alpha and IL-6) and promotes the generation of regulatory T cells.

Anti-inflammatory Action

This leads to reduced systemic inflammation, protection of neuronal tissue from immune-mediated damage, and restoration of immune homeostasis.

03Human evidence

Limited direct human clinical data is available.

Currently, cortistatin has primarily been studied in animal models and in vitro human cell cultures, with very limited direct human clinical trials evaluating its efficacy for autoimmune diseases.

04Preclinical evidence

Significant reduction of arthritis severity.

In murine models of rheumatoid arthritis, cortistatin administration significantly reduced joint inflammation and bone destruction.

Protection in inflammatory bowel disease (IBD).

Animal models of colitis showed that cortistatin treatment improved clinical scores and reduced mucosal damage by balancing immune responses.

05What is known vs. unknown

Reasonably established

Structurally similar to somatostatin but possesses unique functions, including sleep regulation and immune modulation.
Exhibits potent anti-inflammatory effects across various animal models of autoimmune diseases.
Promotes immune tolerance by inducing regulatory T cells and inhibiting inflammatory macrophages.
Shows potential neuroprotective effects in models of multiple sclerosis and neurodegeneration.

Unknowns & limits

Lack of large-scale human clinical trials to confirm safety and efficacy in humans.
Optimal dosing, half-life, and delivery methods in humans remain largely undetermined.
Potential off-target effects due to its broad receptor binding profile.

06Safety & regulatory context

Regulatory statusCortistatin is currently an investigational compound and is not FDA-approved for the treatment of any disease. Because it binds to somatostatin receptors, potential side effects could theoretically include gastrointestinal disturbances, alterations in glucose metabolism, and suppression of certain hormones, similar to somatostatin analogs. Its safety profile in humans has not been fully established, and it remains strictly for laboratory research purposes.

07Compared with Somatostatin

Cortistatin vs. Somatostatin

Key difference

While both bind to somatostatin receptors, cortistatin uniquely binds to the ghrelin receptor and has distinct roles in sleep induction and more pronounced immunomodulatory effects.

When researchers discuss each

Somatostatin is typically discussed in the context of endocrine regulation and inhibiting hormone secretion, whereas cortistatin is highlighted for its potential in treating inflammatory and autoimmune disorders.

08Glossary

Neuropeptide

A small protein-like molecule used by neurons to communicate with each other.

Regulatory T cells (Tregs)

A specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance.

Cytokines

Small proteins crucial in controlling the growth and activity of other immune system cells and blood cells.

09Knowledge check

Q1Which unique receptor does cortistatin bind to that somatostatin does not?

Q2What is a primary research interest for cortistatin based on preclinical models?

Q3Which limitation described in the dossier most directly constrains conclusions about cortistatin's effects in humans?

Q4When researchers contrast cortistatin with somatostatin, cortistatin is particularly highlighted for which role?

Q5Which statement best reflects cortistatin's regulatory and safety status as reported in the dossier?

10Sources

PubMed Cortistatin, a new anti-inflammatory peptide
PubMed Cortistatin: a new player in the immune system

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Research and educational use onlyNothing on this site is medical advice, a prescription, or a recommendation for human use. Compounds documented here are research chemicals. Consult a qualified clinician before making any health decision.