Semax

Human clinical Cognitive Enhancement In 1 protocol 3 sources

Semax is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) that has been extensively studied for its neuroprotective and cognitive-enhancing properties. Research indicates it may modulate brain-derived neurotrophic factor (BDNF) and protect neurons from hypoxic damage, making it a subject of interest in stroke recovery and cognitive decline.

01Dosing reference

Amount

200-1000 mcg per day

Frequency

1-3 times daily

Cycle

2-4 weeks on, followed by an equal time off

Reference figures, not a recommendationThese values reflect amounts described in the literature and vendor documentation this database indexes. Use the reconstitution calculator to convert them into syringe units.

02Mechanism of action

ACTH Receptor Modulation

Acts as an analogue of ACTH(4-10), binding to melanocortin receptors without hormonal activity.

BDNF and TrkB Upregulation

Increases the expression of Brain-Derived Neurotrophic Factor (BDNF) and its receptor TrkB in the hippocampus and forebrain.

Neuroprotection and Cognitive Enhancement

Enhances neuronal survival under stress, improves memory formation, and accelerates recovery from ischemic events.

03Human evidence

Improved recovery outcomes in acute ischemic stroke patients.

Clinical trials in Russia demonstrated that early administration of Semax significantly improved neurological recovery and reduced disability in stroke patients.

Enhanced cognitive performance and memory in healthy individuals under stress.

Studies on healthy volunteers showed improved attention and memory retention during highly demanding tasks.

04Preclinical evidence

Protection against hypoxic damage in neuronal cells.

In vitro and animal models showed increased cell survival and reduced apoptosis when exposed to low oxygen levels.

Stimulation of neurogenesis and synaptic plasticity.

Rodent studies demonstrated increased BDNF levels and enhanced synaptic connections in the hippocampus following Semax administration.

05What is known vs. unknown

Reasonably established

Derived from a fragment of adrenocorticotropic hormone (ACTH).
Administered primarily via intranasal drops for direct brain access.
Increases BDNF levels, supporting neuronal health and cognitive function.
Has a long history of clinical use in Russia for stroke and cognitive disorders.

Unknowns & limits

Lack of large-scale, multi-center clinical trials outside of Eastern Europe.
Long-term effects of continuous use in healthy individuals for cognitive enhancement remain under-researched.

06Safety & regulatory context

Regulatory statusSemax is generally considered safe with a low incidence of side effects when used at recommended dosages. Mild side effects may include nasal irritation from the delivery method. It is an approved medication in Russia and some neighboring countries for conditions like stroke, cognitive impairment, and optic nerve diseases. However, it is not approved by the FDA in the United States and is typically sold as a research chemical or dietary supplement for cognitive enhancement.

07Compared with Selank

Semax vs. Selank

Key difference

While both are Russian-developed peptides, Semax is primarily stimulating and cognitive-enhancing (derived from ACTH), whereas Selank is primarily anxiolytic and calming (derived from tuftsin).

When researchers discuss each

Researchers discuss Semax when focusing on neuroprotection, stroke recovery, and focus enhancement, while Selank is discussed in the context of anxiety reduction, stress management, and mood stabilization.

08Appears in protocols

🧠 Cognitive Enhancement Protocol

200-500 mcg/dayDaily

09Glossary

BDNF (Brain-Derived Neurotrophic Factor)

A protein that promotes the survival of nerve cells and plays a key role in memory, learning, and higher thinking.

Nootropic

A substance that may improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals.

Ischemic Stroke

A type of stroke that occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients.

10Knowledge check

Q1What is the primary mechanism by which Semax is believed to exert its neuroprotective effects?

Q2How is Semax most commonly administered to achieve its cognitive and neuroprotective effects?

Q3Which of the following best describes a documented limitation of the clinical evidence for Semax, according to the dossier?

Q4Based on the dossier’s comparison, in which research contexts are Semax and Selank primarily discussed?

Q5Which statement most accurately reflects the dossier’s safety and regulatory context for Semax?

11Sources

More in Cognitive Enhancement

See all

Selank

Cognitive Enhancement

Human clinical

Selank is a synthetic heptapeptide analogue of the naturally occurring immunomodulatory peptide tuftsin. It has been extensively researched for its anxiolytic (anti-anxiety) and nootropic (cognitive-enhancing) properties, showing the ability to reduce stress and improve memory without the sedative side effects typical of traditional anti-anxiety medications.

250-500 mcg per day (often administered via nasal spray or SubQ)

Dihexa

Cognitive Enhancement

Preclinical only

Dihexa is an oligopeptide variant derived from angiotensin IV that binds to hepatocyte growth factor (HGF) and its receptor c-Met. Research in animal models suggests it has profound synaptogenic and neurogenic properties, showing potential for improving cognitive function and repairing brain damage in conditions like Alzheimer's disease and traumatic brain injury.

10-20 mg/day (oral/sublingual) or 2-5 mg/day (SubQ)

Nemifitide

Cognitive Enhancement

Human clinical

Nemifitide (INN-00835) is a novel synthetic pentapeptide analog of melanocyte-inhibiting factor (MIF-1). Research indicates it may possess rapid-acting antidepressant properties, showing efficacy in clinical trials for major depressive disorder within days rather than weeks.

30-45 mg/day

Research and educational use onlyNothing on this site is medical advice, a prescription, or a recommendation for human use. Compounds documented here are research chemicals. Consult a qualified clinician before making any health decision.